From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I-Extrapolation of a Covariate Model From Morphine to Zidovudine
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چکیده
منابع مشابه
From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine
New approaches to expedite the development of safe and effective pediatric dosing regimens and first-in-child doses are urgently needed. Model-based approaches require quantitative functions on the maturation of different metabolic pathways. In this study, we directly incorporated a pediatric covariate model for the glucuronidation of morphine into a pediatric population model for zidovudine gl...
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ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2012
ISSN: 2163-8306
DOI: 10.1038/psp.2012.11